#5737 THE ASSOCIATION OF SERUM IRISIN WITH EARLY PATENCY LOSS OF ARTERIOVENOUS FISTULA

Abstract Background and Aims In patients receiving hemodialysis (HD), arteriovenous fistula (AVF) is the preferred form of vascular access owing to its long-term patency low risk infection. Early loss AVF (≤1 year) associated with higher mortality morbidity. Irisin thought play a protective role in regulation endothelial function calcification. However, relationship between serum irisin level early unclear. Method 73 end-stage kidney disease (ESKD) patients, including pre-dialysis who receive placement for first time (n = 10), HD 24), that lose more than 1 year 39), fasting (>8 hours) levels other biochemical parameters (hemoglobin, albumin, calcium, phosphate, intact parathyroid hormone, triglyceride, total cholesterol, D-Dimer, fibrinogen, FGF23, C-reactive protein) were measured before or after thrombosis. All had radial-cephalic fistula. Results Among (median age 58 years, 60.3% male, 31.5% diabetes mellitus (DM)), significantly levels, lower compared two groups. Other characteristics no significant difference among these three groups (shown Table 1). Conclusion whose maintained year. The increase may be related putative compensatory mechanisms against injury, which then lost longer dialysis duration aggravated damage.